Influenza – The Lancet

Influenza is an acute respiratory illness, caused by influenza A, B, and C viruses,that occurs in local outbreaks or seasonal epidemics. Clinical illness follows a shortincubation period and presentation ranges from asymptomatic to fulminant, dependingon the characteristics of both the virus and the individual host. Influenza A virusescan also cause sporadic infections or spread worldwide in a pandemic when novel strainsemerge in the human population from an animal host. New approaches to influenza preventionand treatment for management of both seasonal influenza epidemics and pandemics aredesirable.

Source: Influenza – The Lancet

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion | Science

Normally, the lumen of the colon lacks oxygen. Fastidiously anaerobic butyrate-producing bacteria thrive in the colon; by ablating these organisms, antibiotic treatment removes butyrate. Byndloss et al. discovered that loss of butyrate deranges metabolic signaling in gut cells (see the Perspective by Cani). This induces nitric oxidase to generate nitrate in the lumen and disables β-oxidation in epithelial cells that would otherwise mop up stray oxygen before it enters the colon. Simultaneously, regulatory T cells retreat, and inflammation is unchecked, which contributes yet more oxygen species to the colon. Then, facultative aerobic pathogens, such as Escherichia coli and Salmonella enterica , can take advantage of the altered environment and outgrow any antibiotic-crippled and benign anaerobes.Science , this issue p. [570][1]; see also p. [548][2] [1]: /lookup/doi/10.1126/science.aam9949 [2]: /lookup/doi/10.1126/science.aao2202

Source: Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion | Science